Sep 16, 2025 6 min read Daily Rundown

🛎️ Harvard’s AI Eats Pharma

Plus: Vibe Coding Breakpoint, Oakland’s AI Coaching Trial

Good Morning, AI Enthusiasts!

AI isn’t waiting politely at the door. It’s eating pharma, bending how we build software, and even rewriting what it means to coach a team.

NEW TECH

Harvard’s AI Goes Cellular

📌 What’s happening: Harvard Medical School unveiled PDGrapher, a free AI model that maps the tangled web of genes, proteins, and signaling pathways to propose therapies that could restore diseased cells to health. In trials across 11 cancer types, it ranked correct drug targets up to 35% higher and 25x faster than existing tools.

🧠 How this hits reality: Traditional pharma spends billions “taste-testing” compounds one by one; PDGrapher acts like a systems chef, mixing multiple pathways at once. If it scales, the moat shifts from brute-force lab trials to whoever controls the best cell-state datasets. CROs, legacy big-pharma discovery units, and even clinical trial timelines just got a serious time-to-kill warning.

🛎️ Key takeaway: AI isn’t just spotting tumors—it’s rewriting biology’s recipe book. If PDGrapher works, pharma’s billion-dollar bottleneck just became software-speed.

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🚀 Qoder Officially Launches Pro Plans

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CODING

Vibe Coding Kills the Old Playbook

📌 What’s happening: Veteran engineers see vibe coding as babysitting gone wrong — endless bug-hunting after AI’s messy commits. But AI Secret’s talks with AI startup teams like Qoder and Bika.ai show a sharper edge: when teams drive coding directly from business logic, vibe coding doesn’t just replace the manual write-debug cycle, it slashes hallucinations by cutting out code divorced from context.

🧠 How this hits reality: Startups that fuse product requirements with AI prompts are turning vibe coding into a business-first workflow, not a technical sideshow. Instead of senior devs patching leaks, founders are prototyping, iterating, and shipping with speed that sidesteps many of the hallucination traps. The future isn’t code vs. AI — it’s code as an extension of business reasoning.

🛎️ Key takeaway: Vibe coding’s real unlock isn’t faster code — it’s collapsing the wall between strategy and syntax.

SPORT

Oakland’s AI Coaching Trial

📌 What’s happening: The Oakland Ballers ran an unusual experiment, handing over managerial duties to an AI app, “AaronLytics,” during a Pioneer League game. The system built lineups, called pitching changes, picked pinch hitters, and even nominated the “Beer Batter.” While engineers had to patch in missing data and rules on the fly, the AI’s calls — combined with the manager’s oversight — guided the team to a 3–2 win.

🧠 How this hits reality: Sports has leaned on analytics since Moneyball, but this is the first time an AI system directly made in-game calls. The experiment showed that AI can process stats and suggest strategies fast, while human managers still supply context, judgment, and rule awareness. The more realistic future isn’t man versus machine, but a dugout where human intuition and algorithmic precision reinforce each other.

🛎️ Key takeaway: This trial run suggests AI won’t replace managers, but it may reshape what “coaching” means in the first place.

QUICK HITS

CrowdStrike and Meta launched CyberSOCEval, an open-source benchmark to help businesses choose effective AI cybersecurity models.
Microsoft rolls out free Copilot Chat in Office apps for all Microsoft 365 business users, while keeping advanced GPT-5 features behind a $30/month license.
Reuters and a Harvard researcher found major AI chatbots can be coaxed into phishing scams, with senior tests showing real risks of AI-driven fraud.
Anthropic’s Economic Index shows business automation with Claude jumped from 27% to 39% in 2025, underscoring growing enterprise trust in AI.
OpenAI launched GPT-5-Codex, a model that can autonomously handle long, complex coding tasks, boosting refactoring efficiency and offering faster, more intuitive developer workflows.

TRENDING

Daily AI Launches

Blocks has launched a unified platform with an AI builder, Ella, that turns plain language into both smart work apps and AI agents in minutes.
Cal.ai has launched a new Phone Agent that uses lifelike AI to book meetings, send reminders, and handle follow-ups over natural phone calls.
SnowSEO has launched v2.0, an all-in-one, automated SEO platform that boosts rankings and drives growth from both traditional search engines and new AI platforms.
My Financé has launched a personal finance tool that provides clear insights into your spending with a simple, one-time setup and no manual data entry.

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